Map & Directions to Technik Museums X 2
Take A6 east toward Mannheim, exiting onto A61 at the Kreuz Frankenthal Exit 21. Continue on A61 direction Speyer/Karlsruhe. If visiting Speyer museum, get off at exit  # 63, B9 toward Speyer/Germersheim. Follow signs to the Am Technik Museum, toward Speyer Zentrum.  If visiting Sinsheim, don't exit at #63 but continue on A61 toward Hockenheim. The autobahn will merge with A6 and continue to Sinsheim. Take Exit #33 or 33b) and follow the signs a short distance to the museum. 
Speyer's Romanesque cathedral and Old Town is adjacent to the "Dompark" next to the museum.
Both museums are marked with clear signs once you exit the autobahn.  The museum is  accessible from the Exit 33 or 33b, Sinsheim - just follow the signs.